From I-20: Take the Pine Street exit and go south to Vogel street. Take a right and you are on the HSU campus.

From San Antonio (83/84): Follow 83 (which is Treadaway street) through town until you reach Ambler Ave. (its about seven miles). Take a left on Ambler and go through one stop light and the Hardin-Simmons main entrance is the next stop light on your right.

From Brownwood (36): Stay on 36 until you come to Judge Ely Ave. Make a right at the light and go to Ambler (approx. 2 miles). Take a left on Ambler and go through three stop lights and the Hardin-Simmons main entrance is the next stop light on your right.